Large genome model: Open source AI trained on trillions of bases

Late in 2025, we covered the development of an AI system called Evo that was trained on massive numbers of bacterial genomes. So many that, when prompted with sequences from a cluster of related genes ...
Open Access Government

Unusual DNA structures and misfolded proteins

Alan Herbert, Founder and President of InsideOutBio, discusses the evolution of biological concepts related to DNA and protein structures ...
IEEE

Fusion-Based Deep Learning Architecture for Detecting Drug-Target Binding Affinity Using Target and Drug Sequence and Structure

Abstract: Accurately predicting drug-target binding affinity plays a vital role in accelerating drug discovery. Many computational approaches have been proposed due to costly and time-consuming of wet ...
Medical Xpress

Repetitive Sequences, Nucleic Acid

Scientists at St. Jude Children's Research Hospital have revealed previously unappreciated roles for the retrotransposon LINE-1 in shaping the cancer genome structure and regulation. Retrotransposons ...
eLife

Interpretable protein-DNA interactions captured by structure-sequence optimization

This valuable work presents an interpretable protein-DNA Energy Associative (IDEA) model for predicting binding sites and affinities of DNA-binding proteins. While the method is convincing, it ...
GEN

Gero’s Structure-Free AI Model Generates Small Molecules from Protein Sequences

Gero, a biotechnology company developing novel therapeutics for aging and chronic diseases, has released ProtoBind-Diff, a novel masked diffusion language model that generates drug-like molecules for ...
marktechpost

PLAID: A New AI Approach for Co-Generating Sequence and All-Atom Protein Structures by Sampling from the Latent Space of ESMFold

Designing accurate all-atom protein structures is a critical challenge in bioengineering, as it involves generating both 3D structural data and 1D sequence information to define side-chain atom ...
Forbes

Timely OpenJDK Migration For Efficient Java Run

Alexander Belokrylov is CEO of BellSoft. Accomplished expert in Java technology and IT leadership with over 10 years of experience. Software applications are today's basic operations layer for any ...